Sirona may refer to
- Sirona (goddess), Celtic deity
- Dentsply Sirona, company created in the 2016 merger of Sirona Dental Systems with Dentsply International
- Sirona Care & Health, British community interest company
- 116 Sirona, main-belt asteroid
- Sirona Ryan, fictional character in the 2023 video game Hogwarts Legacy
- USS Sirona (1945-1966), American Navy ship