Sirota, Sierota, Sirotta or Syrota (Cyrillic: сирота) is a gender-neutral Slavic surname meaning orphan. Notable people with the surname include:
- Alexander Sirota (born 1976), Ukrainian photographer
- Beate Sirota (1923–2012), American performing arts director
- Benny Sirota (?–?), one of the founders of the Troika Pottery
- David Sirota (born 1975), American writer
- Gershon Sirota (1874–1943), Ukrainian musician
- Leo Sirota (1885–1965), Ukrainian pianist
- Louanne Sirota (born 1970), American actress
- Lyubov Sirota (born 1956), Ukrainian writer
- Milton Sirotta (1911–1981), American who coined the word "googol"
- Nick Sirota (born 1984), American ice hockey player
- Ruslan Sirota (born 1980), Ukrainian musician
- Oleksandr Syrota (born 2000), Ukrainian footballer
- Sydney Sierota, American musician
- Svyatoslav Syrota (born 1970), Ukrainian football player and administrator