Alfred Sisley (1839–1899) was a French impressionist painter of English origin.
Sisley may also refer to:
- Tomer Sisley (born 1974), an Israeli French humorist and actor
- 6675 Sisley, a main-belt asteroid
- Sisley Volley, a professional volleyball team based in Belluno, Italy
- Sue Sisley, an American psychiatrist
- Sisley, a fashion brand, owned by the Benetton Group established in 1974
- Sisley Choi, (born 1991) a Hong Kong TVB actress
- Sisley (company), a French skin care and perfume brand