Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.[5][6] This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.[6]

SIVA1
Identifiers
AliasesSIVA1, CD27BP, SIVA, Siva-1, Siva-2, SIVA1 apoptosis inducing factor
External IDsOMIM: 605567; MGI: 1353606; HomoloGene: 4692; GeneCards: SIVA1; OMA:SIVA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006427
NM_021709

NM_001161737
NM_013929

RefSeq (protein)

NP_006418
NP_068355

NP_001155209
NP_038957

Location (UCSC)Chr 14: 104.75 – 104.77 MbChr 12: 112.61 – 112.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

edit

SIVA1 has been shown to interact with CD27.[5]

Siva (protein)

edit

Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. [7]

See also

edit

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184990Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064326Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jul 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc Natl Acad Sci U S A. 94 (12): 6346–51. Bibcode:1997PNAS...94.6346P. doi:10.1073/pnas.94.12.6346. PMC 21052. PMID 9177220.
  6. ^ a b "Entrez Gene: SIVA1 SIVA1, apoptosis-inducing factor".
  7. ^ Fortin A, MacLaurin JG, Arbour N, et al. (July 2004). "The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1". J. Biol. Chem. 279 (27): 28706–14. doi:10.1074/jbc.M400376200. PMID 15105421.

Further reading

edit