Sixer or Sixers may refer to:
- Sixer (2007 film), an Indian Kannada-language film
- Sixer (2019 film), an Indian Tamil-language film
- Philadelphia 76ers, a professional basketball team in Philadelphia, Pennsylvania, United States
- Fort Worth Sixers, a National Indoor Football League franchise in the United States
- Cricket:
- Sydney Sixers, an Australian cricket franchise
- Sixer (cricket), an act of scoring six runs
- Southern Sixers, mountains in the southern United States which are at least six thousand feet tall
- Stephen Kellogg and the Sixers, an American rock band
- The members of the sixth pilgrimage to Terra Nova, the settlement in the U.S. TV series of the same name
- Sixer, the slang term for a 6-litre bottle of water.
- Sixer, a member of a Cub Pack who leads a team called a "Six"
- Sixers, the slang term for members of the IOI in Ready Player One