Skiles may refer to:
- People
- Scott Skiles, born 1964, an American basketball player
- Wesley C. Skiles, (1958–2010), American cave diving pioneer
- William W. Skiles, William Woodburn Skiles (1849–1904) was a U.S. Politician
- William Vernon Skiles, (1879–1947), American mathematician
- William West Skiles
- Skiles and Henderson, US comedy duo
- Jeff Skiles
- Places