Slx1 structure-specific endonuclease subunit homolog b (s. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) is a protein in humans that is encoded by the SLX1B gene.

SLX1B
Identifiers
Aliases	SLX1B, GIYD2, Slx1 structure-specific endonuclease subunit homolog b, SLX1 homolog B, structure-specific endonuclease subunit
External IDs	OMIM: 615823; MGI: 1915220; HomoloGene: 11434; GeneCards: SLX1B; OMA:SLX1B - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 29,454,501 bp End 29,458,219 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 126,288,640 bp End 126,294,956 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum monocyte appendix placenta ventricular zone bone marrow cells blood muscle of thigh ganglionic eminence stromal cell of endometrium Top expressed in neural layer of retina lumbar subsegment of spinal cord aortic valve morula ascending aorta ventricular zone yolk sac lens superior frontal gyrus granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function nuclease activity endonuclease activity protein binding hydrolase activity metal ion binding 5'-flap endonuclease activity endodeoxyribonuclease activity crossover junction endodeoxyribonuclease activity Cellular component nucleus nucleoplasm Slx1-Slx4 complex Biological process DNA double-strand break processing involved in repair via single-strand annealing cellular response to DNA damage stimulus DNA recombination interstrand cross-link repair positive regulation of t-circle formation nucleic acid phosphodiester bond hydrolysis DNA repair double-strand break repair via homologous recombination telomere maintenance via telomere lengthening t-circle formation negative regulation of telomere maintenance via telomere lengthening telomeric D-loop disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79008 75764 Ensembl ENSG00000181625 ENSMUSG00000059772 UniProt Q9BQ83 Q8BX32 RefSeq (mRNA) NM_178044 NM_024044 NM_001400286 NM_001400287 NM_029420 RefSeq (protein) NP_001014999 NP_001015000 NP_083696 Location (UCSC) Chr 16: 29.45 – 29.46 Mb Chr 7: 126.29 – 126.29 Mb PubMed search
Wikidata
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This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010].