Small intensely fluorescent cell

Small intensely fluorescent cells (SIF cells) are the interneurons of the sympathetic ganglia (postganglionic neurons) of the Sympathetic division of the autonomic nervous system (ANS). The neurotransmitter for these cells is dopamine. They are a neural crest derivative and share a common sympathoadrenal precursor cell with sympathetic neurons and chromaffin cells (adrenal medulla).

Although an autonomic ganglion is the site where preganglionic fibers synapse on postganglionic neurons, the presence of small interneurons has been recognized. These cells exhibit catecholamine fluorescence and are referred to as small intensely fluorescent (SIF) cells. In some ganglia, these intemeurons receive preganglionic cholinergic fibers and may modulate ganglionic transmission. In other ganglia, they receive collateral branches and may serve some Integrative function. Many SIF cells contain dopamine, which Is thought to be their transmitter.

Further reading

• Matthews, Margaret R. (1989). "Small, intensely fluorescent cells and the paraneuron concept". Journal of Electron Microscopy Technique. 12 (4): 408–416. doi:10.1002/jemt.1060120413. PMID 2671307.
• Eränkö, Olavi; Eränkö, Liisa (1971). "Small, Intensely Fluorescent Granule-containing Cells in the Sympathetic Ganglion of the Rat". Progress in Brain Research Volume 34. Vol. 34. pp. 39–51. doi:10.1016/S0079-6123(08)63952-7. ISBN 978-0-444-40951-5.
• Doupe, AJ; Patterson, PH; Landis, SC (1985). "Small intensely fluorescent cells in culture: Role of glucocorticoids and growth factors in their development and interconversions with other neural crest derivatives". The Journal of Neuroscience. 5 (8): 2143–2160. doi:10.1523/JNEUROSCI.05-08-02143.1985. PMC 6565283. PMID 4020433.
• Eranko, O. (1978). "Small Intensely Fluorescent (SIF) Cells and Nervous Transmission in Sympathetic Ganglia". Annual Review of Pharmacology and Toxicology. 18: 417–430. doi:10.1146/annurev.pa.18.040178.002221. PMID 206195.
• Eränkö, Olavi, ed. (1976). SIF Cells: Structure and Function of the Small, Intensely Fluorescent Sympathetic Cells. hdl:2027/mdp.39015007131090. OCLC 561304650.
• Eränkö, Liisa; Eränkö, Olavi (1972). "Effect of Guanethidine on Nerve Cells and Small Intensely Fluorescent Cells in Sympathetic Ganglia of Newborn and Adult Rats". Acta Pharmacologica et Toxicologica. 30 (5–6): 403–416. doi:10.1111/j.1600-0773.1972.tb00672.x. PMID 4335184.
• Williams, T. H.; Black, A. C.; Chiba, T.; Bhalla, R. C. (1975). "Morphology and biochemistry of small, intensely fluorescent cells of sympathetic ganglia". Nature. 256 (5515): 315–317. Bibcode:1975Natur.256..315W. doi:10.1038/256315a0. PMID 167287. S2CID 4215710.
• Tanaka, Koichi; Chiba, Tanemichi (1996). "Microvascular organization of sympathetic ganglia, with special reference to small intensely-fluorescent cells". Microscopy Research and Technique. 35 (2): 137–145. doi:10.1002/(SICI)1097-0029(19961001)35:2<137::AID-JEMT4>3.0.CO;2-N. PMID 8923448. S2CID 6487851.
• Chiba, T.; Williams, T.H. (1975). "Histofluorescence characteristics and quantification of small intensely fluorescent (SIF) cells in sympathetic ganglia of several species". Cell and Tissue Research. 162 (3): 331–341. doi:10.1007/BF00220179. PMID 810244. S2CID 34547256.
• Takaki, Fumiya; Nakamuta, Nobuaki; Kusakabe, Tatsumi; Yamamoto, Yoshio (2015). "Sympathetic and sensory innervation of small intensely fluorescent (SIF) cells in rat superior cervical ganglion". Cell and Tissue Research. 359 (2): 441–451. doi:10.1007/s00441-014-2051-1. PMID 25416508. S2CID 18071128.