Small nuclear ribonucleoprotein polypeptide C

U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.

SNRPC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VRD, 3CW1, 4PJO
Identifiers
Aliases	SNRPC, U1C, Yhc1, Small nuclear ribonucleoprotein polypeptide C
External IDs	OMIM: 603522; MGI: 109489; HomoloGene: 136764; GeneCards: SNRPC; OMA:SNRPC - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.31 Start 34,757,505 bp End 34,773,857 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 28,057,124 bp End 28,070,942 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left testis right testis right auricle left ventricle mucosa of transverse colon ventricular zone ganglionic eminence muscle of thigh gastrocnemius muscle Top expressed in yolk sac ventricular zone embryo morula embryo neural layer of retina muscle of thigh granulocyte blastocyst lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity zinc ion binding metal ion binding protein binding single-stranded RNA binding nucleic acid binding U1 snRNA binding pre-mRNA 5'-splice site binding U1 snRNP binding RNA binding mRNA binding Cellular component Cajal body prespliceosome U1 snRNP nucleus commitment complex nucleoplasm U2-type prespliceosome Biological process spliceosomal snRNP assembly mRNA 5'-splice site recognition mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6631 20630 Ensembl ENSG00000124562 ENSMUSG00000024217 UniProt P09234 Q62241 RefSeq (mRNA) NM_003093 NM_011432 RefSeq (protein) NP_003084 NP_035562 Location (UCSC) Chr 6: 34.76 – 34.77 Mb Chr 17: 28.06 – 28.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Small nuclear ribonucleoprotein polypeptide C has been shown to interact with Ewing sarcoma breakpoint region 1.

Further reading

• Yamamoto K, Miura H, Moroi Y, Yoshinoya S, Goto M, Nishioka K, Miyamoto T (January 1988). "Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide". Journal of Immunology. 140 (1): 311–7. doi:10.4049/jimmunol.140.1.311. PMID 2961811. S2CID 45846091.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nelissen RL, Gunnewiek JM, Lambermon MH, Van Venrooij WJ (January 1997). "Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C". Gene. 184 (2): 273–8. doi:10.1016/S0378-1119(96)00612-9. hdl:2066/27882. PMID 9031639.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dumortier H, Klein Gunnewiek J, Roussel JP, van Aarssen Y, Briand JP, van Venrooij WJ, Muller S (December 1998). "At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle". Nucleic Acids Research. 26 (23): 5486–91. doi:10.1093/nar/26.23.5486. PMC 147990. PMID 9826776.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
• Knoop LL, Baker SJ (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". The Journal of Biological Chemistry. 275 (32): 24865–71. doi:10.1074/jbc.M001661200. PMID 10827180.
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Förch P, Puig O, Martínez C, Séraphin B, Valcárcel J (December 2002). "The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites". The EMBO Journal. 21 (24): 6882–92. doi:10.1093/emboj/cdf668. PMC 139089. PMID 12486009.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.