Small nuclear ribonucleoprotein polypeptide F

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

SNRPF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR
Identifiers
Aliases	SNRPF, SMF, Sm-F, snRNP-F, Small nuclear ribonucleoprotein polypeptide F
External IDs	OMIM: 603541; MGI: 1917128; HomoloGene: 130366; GeneCards: SNRPF; OMA:SNRPF - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q23.1 Start 95,858,952 bp End 95,903,828 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C2 Start 93,418,891 bp End 93,425,568 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte embryo ganglionic eminence epithelium of colon ventricular zone mucosa of pharynx bone marrow mucosa of transverse colon oral cavity pericardium Top expressed in yolk sac embryo embryo epiblast ventricular zone ganglionic eminence lens zygote neural tube placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component U4 snRNP SMN-Sm protein complex pICln-Sm protein complex nucleus U7 snRNP catalytic step 2 spliceosome U1 snRNP cytoplasm sno(s)RNA-containing ribonucleoprotein complex nucleoplasm small nuclear ribonucleoprotein complex U12-type spliceosomal complex methylosome cytosol spliceosomal complex U2-type catalytic step 2 spliceosome U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome Biological process termination of RNA polymerase II transcription histone mRNA metabolic process mRNA processing mRNA splicing, via spliceosome RNA splicing import into nucleus spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6636 69878 Ensembl ENSG00000139343 ENSMUSG00000020018 UniProt P62306 P62307 RefSeq (mRNA) NM_003095 NM_001394209 NM_027246 RefSeq (protein) NP_003086 NP_081522 Location (UCSC) Chr 12: 95.86 – 95.9 Mb Chr 10: 93.42 – 93.43 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Small nuclear ribonucleoprotein polypeptide F has been shown to interact with DDX20, Small nuclear ribonucleoprotein D2 and Small nuclear ribonucleoprotein polypeptide E.

Further reading

• Sauterer RA, Goyal A, Zieve GW (January 1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts". The Journal of Biological Chemistry. 265 (2): 1048–58. doi:10.1016/S0021-9258(19)40157-9. PMID 1688550.
• Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (April 1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". The Journal of Biological Chemistry. 264 (10): 5776–83. doi:10.1016/S0021-9258(18)83617-1. PMID 2522439.
• Woppmann A, Rinke J, Lührmann R (December 1988). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ". Nucleic Acids Research. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Plessel G, Lührmann R, Kastner B (January 1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
• Bühler D, Raker V, Lührmann R, Fischer U (December 1999). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Human Molecular Genetics. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
• Urlaub H, Raker VA, Kostka S, Lührmann R (January 2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". The EMBO Journal. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". The Journal of Biological Chemistry. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R (June 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (June 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.