In molecular biology, small nucleolar RNA SNORA11 (also known as U107) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).
| Small nucleolar RNA SNORA11 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA11 | |
| Identifiers | |
| Symbol | SNORA11 |
| Rfam | RF00614 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; H/ACA-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000594 |
| PDB structures | PDBe |
U107 has a predicted hairpin-hinge-hairpin-tail structure and is predicted to be a member of the H/ACA box class of snoRNAs that guide the sites of modification of uridines to pseudouridines.[1] This snoRNA was identified by RT-PCR from blood cells and its expression confirmed by Northern blot analysis.[2] There is no predicted RNA target for this guide snRNA.[3]
References
edit- ^ Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
- ^ Gu AD, Zhou H, Yu CH, Qu LH (December 2005). "A novel experimental approach for systematic identification of box H/ACA snoRNAs from eukaryotes". Nucleic Acids Research. 33 (22): e194. doi:10.1093/nar/gni185. PMC 1316117. PMID 16361266.
- ^ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158–162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
External links
edit- Page for Small nucleolar RNA SNORA11 at Rfam
- Entry for SNORA11 at snoRNABase
- HGNC page for Small nucleolar RNA SNORA11
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