In molecular biology, Homo sapiens snoRA35 (also known as HBI-36) is an H/ACA box snoRNA, first cloned from a mouse adult brain cDNA library by Cavaillé et al. (2000),[1] and is found to be specifically expressed in the choroid plexus. Its human orthologue, HBI-36 was discovered by a homology search and was discovered to be specifically expressed in the brain. Its gene resides in the second intron of the serotonin receptor 2c (5HT-2c) gene, which is predominantly expressed in choroid plexus epithelial cells. The human 5HT-2c mRNA was predicted to be 2'-O-methylated by the C/D box snoRNP HBII-52 at a position also subjected to A-to-I editing. HBI-36 has no documented RNA target.
| Small nucleolar RNA SNORA35 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA35 | |
| Identifiers | |
| Symbol | SNORA35 |
| Alt. Symbols | snoHBI-36 |
| Rfam | RF00566 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; HACA-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000594 |
| PDB structures | PDBe |
References
edit- ^ Cavaillé J, Buiting K, Kiefmann M, Lalande M, Brannan CI, Horsthemke B, Bachellerie JP, Brosius J, Hüttenhofer A (December 2000). "Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14311–6. doi:10.1073/pnas.250426397. PMC 18915. PMID 11106375.
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