In molecular biology, the small nucleolar RNA ACA40 belongs to the H/ACA family of snoRNAs and guides the pseudouridylation of 28S rRNA subunit at position U4565. snoRNA ACA40 was discovered using large-scale cloning by Kiss et al. (2004)[1] from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues 28S rRNA U4546 and 18S rRNA 1174.[1][2] The pseudouridylation of these residues was reported by Ofengand and Bakin (1997)[3] and Maden (1990).[4] ACA1, ACA8, ACA18, ACA25, ACA32 and ACA40 and the C/D box snoRNAs mgh28S-2409 and mgh28S-2411 share the same host gene (MGC5306).
| Small nucleolar RNA SNORA40 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA40 | |
| Identifiers | |
| Symbol | SNORA40 |
| Alt. Symbols | snoACA40 |
| Rfam | RF00561 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; HACA-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000594 |
| PDB structures | PDBe |
References
edit- ^ a b Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
- ^ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.
- ^ Ofengand, J; Bakin A (1997). "Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts". J Mol Biol. 266 (2): 246–268. doi:10.1006/jmbi.1996.0737. PMID 9047361.
- ^ Maden BE (1990). "The numerous modified nucleotides in eukaryotic ribosomal RNA". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 39: 241–303. doi:10.1016/S0079-6603(08)60629-7. ISBN 9780125400398. PMID 2247610.
External links
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