In molecular biology, U14 small nucleolar RNA (U14 snoRNA) is a non-coding RNA required for early cleavages of eukaryotic precursor rRNAs. In yeasts, this molecule possesses a stem-loop region (known as the Y-domain) which is essential for function. A similar structure, but with a different consensus sequence, is found in plants, but is absent in vertebrates.[1] In human there are two closely related copies called SNORD14A and SNORD14B that are expressed from the intron of their host gene ribosomal protein Rps13.
| Small nucleolar RNA SNORD14 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD14 | |
| Identifiers | |
| Symbol | SNORD14 |
| Alt. Symbols | U14 |
| Rfam | RF00016 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
References
edit- ^ Samarsky DA, Schneider GS, Fournier MJ (June 1996). "An essential domain in Saccharomyces cerevisiae U14 snoRNA is absent in vertebrates, but conserved in other yeasts". Nucleic Acids Research. 24 (11): 2059–66. doi:10.1093/nar/24.11.2059. PMC 145897. PMID 8668536.
External links
edit- Page for Small nucleolar RNA SNORD14 at Rfam
- Entry for U14A at snoRNABase
- Entry for SNORD14A in HGNC database[permanent dead link]
- Entry for U14B at snoRNABase
- Entry for SNORD14B in HGNC database[permanent dead link]
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