In molecular biology, snoRNA U38 (also known as SNORD38) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
| Small nucleolar RNA SNORD38 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD38 | |
| Identifiers | |
| Symbol | SNORD38 |
| Alt. Symbols | U38 |
| Rfam | RF00212 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
snoRNA U38 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]
U38 is located in introns 4 and 5 of ribosomal protein S8 in human and in the homologous genes in mouse and cow.[2] U38 is predicted to guides the methylation of 2'-O-ribose residues in 28S ribosomal RNA (rRNA). The mouse homologue of U38 (MBII-329) has also been identified.[3]
References
edit- ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ^ Nicoloso M, Qu LH, Michot B, Bachellerie JP (July 1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". Journal of Molecular Biology. 260 (2): 178–95. doi:10.1006/jmbi.1996.0391. PMID 8764399.
- ^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
External links
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