In molecular biology, snoRNA snR60 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR60 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA snR60 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome,[2] subsequent experimental screens discovered plant homologues Z15, Z230, Z193 and J17[3] and human U80/SNORD80.
| Small nucleolar RNA snR60/Z15/Z230/Z193/J17 | |
|---|---|
 Predicted secondary structure and sequence conservation of snosnR60_Z15 | |
| Identifiers | |
| Symbol | snosnR60_Z15 |
| Alt. Symbols | snoZ193 |
| Rfam | RF00309 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
References
edit- ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ^ Lowe TM, Eddy SR (February 1999). "A computational screen for methylation guide snoRNAs in yeast". Science. 283 (5405): 1168–71. Bibcode:1999Sci...283.1168L. doi:10.1126/science.283.5405.1168. PMID 10024243.
- ^ Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (May 2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Research. 31 (10): 2601–13. doi:10.1093/nar/gkg373. PMC 156054. PMID 12736310.
External links
edit- Page for Small nucleolar RNA snR60/Z15/Z230/Z193/J17 at Rfam
- Link to snR60 at the FournierLab's snoRNAdb.
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