In molecular biology, the snoRNA snoZ7/snoZ77 family contains related non-coding RNA molecules that are members of the C/D class of snoRNA which contain the C box motif (UGAUGA) and the D box motif (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2] snoZ7 RNA guides the methylation of 25S rRNA position A1372, whereas SnoR77Y guides the methylation of 18S rRNA at position U580. This family of snoRNAs has been found in plant species such as Arabidopsis thaliana.
| Small nucleolar RNA snoZ7/snoR77 | |
|---|---|
 Predicted secondary structure and sequence conservation of snoZ7 | |
| Identifiers | |
| Symbol | snoZ7 |
| Alt. Symbols | snoR77 |
| Rfam | RF00268 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
References
edit- ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ^ Marker C, Zemann A, Terhörst T, Kiefmann M, Kastenmayer JP, Green P, Bachellerie JP, Brosius J, Hüttenhofer A (December 2002). "Experimental RNomics: identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana". Current Biology. 12 (23): 2002–13. doi:10.1016/S0960-9822(02)01304-0. PMID 12477388. S2CID 18112420.
External links
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