Smalls is a surname. Notable people with the surname include:
- Bertie Smalls (1935–2008), noted British supergrass
- Biggie Smalls, former name of The Notorious B.I.G.
- Charlie Smalls (1943–1987), composer and songwriter
- Chris Smalls, American labor organizer
- Cliff Smalls (1918-2008), American jazz trombonist, pianist, conductor and arranger
- Fred Smalls (born 1963), American football linebacker
- Joan Smalls, Puerto Rican fashion model
- Robert Smalls (1839–1915), slave who, during and after the American Civil War, became a ship's pilot, sea captain and politician
- Tiger Smalls, American boxing trainer
- Tionna T. Smalls, American author and media personality
- Tommy Smalls (1926-1972), New York radio disc jockey known as "Dr. Jive"
Fictional characters:
- Derek Smalls, bassist in the parody heavy metal band Spinal Tap
- Leonard Smalls, Lone Biker of the Apocalypse in Raising Arizona
- Scotty "You're killin' me" Smalls, fifth-grade protagonist in The Sandlot