Sodium–hydrogen antiporter 2

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.

SLC9A2
Identifiers
Aliases	SLC9A2, NHE2, solute carrier family 9 member A2
External IDs	OMIM: 600530; MGI: 105075; HomoloGene: 20661; GeneCards: SLC9A2; OMA:SLC9A2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q12.1 Start 102,619,553 bp End 102,711,355 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 B|1 19.66 cM Start 40,719,734 bp End 40,808,433 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum testicle mucosa of transverse colon mucosa of sigmoid colon buccal mucosa cell pylorus muscle of thigh body of stomach epithelium of colon gastrocnemius muscle Top expressed in interventricular septum left colon jejunum prostate epithelium of stomach seminal vesicula lobe of prostate extraocular muscle duodenum sternocleidomastoid muscle More reference expression data BioGPS n/a
Gene ontology Molecular function solute:proton antiporter activity antiporter activity potassium:proton antiporter activity sodium:proton antiporter activity Cellular component integral component of membrane membrane plasma membrane Biological process proton transmembrane transport protein localization cation transport ion transport regulation of pH sodium ion transport regulation of intracellular pH sodium ion import across plasma membrane potassium ion transmembrane transport transmembrane transport anion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6549 226999 Ensembl ENSG00000115616 ENSMUSG00000026062 UniProt Q9UBY0 n/a RefSeq (mRNA) NM_003048 NM_001033289 RefSeq (protein) NP_003039 n/a Location (UCSC) Chr 2: 102.62 – 102.71 Mb Chr 1: 40.72 – 40.81 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

Further reading

• Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3". Clinical and Investigative Medicine. 22 (5): 195–206. PMID 10579058.
• Kulanthaivel P, Furesz TC, Moe AJ, et al. (1992). "Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane". Biochem. J. 284 (1): 33–8. doi:10.1042/bj2840033. PMC 1132693. PMID 1318024.
• Collins JF, Honda T, Knobel S, et al. (1993). "Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2)". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 3938–42. Bibcode:1993PNAS...90.3938C. doi:10.1073/pnas.90.9.3938. PMC 46421. PMID 7683411.
• Ghishan FK, Knobel SM, Summar M (1996). "Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2)". Genomics. 30 (1): 25–30. doi:10.1006/geno.1995.0004. PMID 8595899.
• Dudeja PK, Rao DD, Syed I, et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA". Am. J. Physiol. 271 (3 Pt 1): G483–93. doi:10.1152/ajpgi.1996.271.3.G483. PMID 8843774.
• Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. Bibcode:1996PNAS...9312631L. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Chow CW, Woodside M, Demaurex N, et al. (1999). "Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia". J. Biol. Chem. 274 (15): 10481–8. doi:10.1074/jbc.274.15.10481. PMID 10187839.
• Malakooti J, Dahdal RY, Schmidt L, et al. (1999). "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2". Am. J. Physiol. 277 (2 Pt 1): G383–90. doi:10.1152/ajpgi.1999.277.2.G383. PMID 10444453. S2CID 4467617.
• Malakooti J, Dahdal RY, Dudeja PK, et al. (2001). "The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (4): G763–73. doi:10.1152/ajpgi.2001.280.4.G763. PMID 11254504. S2CID 10642872.
• Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
• Repishti M, Hogan DL, Pratha V, et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. doi:10.1152/ajpgi.2001.281.1.G159. PMID 11408268. S2CID 616434.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lacey HA, Nolan T, Greenwood SL, et al. (2005). "Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR". Placenta. 26 (1): 93–8. doi:10.1016/j.placenta.2004.05.005. PMID 15664417.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Pearse I, Zhu YX, Murray EJ, et al. (2007). "Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site". Biochem. J. 407 (1): 101–11. doi:10.1042/BJ20070364. PMC 2267401. PMID 17561809.