Sodium-dependent phosphate transport protein 2B

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.[5][6][7]

SLC34A2
Identifiers
AliasesSLC34A2, NAPI-3B, NAPI-IIb, NPTIIb, solute carrier family 34 member 2, PULAM
External IDsOMIM: 604217; MGI: 1342284; HomoloGene: 2297; GeneCards: SLC34A2; OMA:SLC34A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006424
NM_001177998
NM_001177999

NM_011402

RefSeq (protein)

NP_001171469
NP_001171470
NP_006415

NP_035532

Location (UCSC)Chr 4: 25.65 – 25.68 MbChr 5: 53.2 – 53.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance

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Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen.[8]

As of April 2023, upifitamab rilsodotin, an antibody-drug conjugate (ADC) targeting NaPi2b, is in Phase 3 clinical trials for recurrent platinum-sensitive ovarian cancer.[9]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157765Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029188Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (May 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochemical and Biophysical Research Communications. 258 (3): 578–582. doi:10.1006/bbrc.1999.0666. PMID 10329428.
  6. ^ Xu H, Bai L, Collins JF, Ghishan FK (December 1999). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics. 62 (2): 281–284. doi:10.1006/geno.1999.6009. PMID 10610722.
  7. ^ "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".
  8. ^ Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, et al. (February 2008). "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immunity. 8: 3. PMC 2935786. PMID 18251464.
  9. ^ Clinical trial number NCT05329545 for "Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer (UP-NEXT)." at ClinicalTrials.gov

Further reading

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