Sodium astatide

Sodium astatide
Names
	Preferred IUPAC name Sodium astatide
Identifiers
3D model (JSmol)	Interactive image;
	SMILES [Na+].[At-];
Properties
Chemical formula	NaAt
Thermochemistry
Std enthalpy of; formation (ΔfH⦵298)	−257 kJ/mol (estimated)
Related compounds
Related compounds	Magnesium astatide
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Sodium astatide is a binary inorganic compound of sodium and astatine with the chemical formula NaAt.^[2]^[3]

Synthesis

Sodium astatide solution has been prepared by distilling astatine from the bismuth alpha-ray target where it was prepared, dissolving in sodium bicarbonate solution, and reducing At⁺ and At³⁺ ions with ascorbic acid.^[4]

Uses

Sodium astatide has been proposed for use in radiation therapy to replace ¹³¹I.^[5]^[4]

References

^ Burgers, Peter C.; Zeneyedpour, Lona; Luider, Theo M.; Holmes, John L. (2024). "Estimation of thermodynamic and physicochemical properties of the alkali astatides: On the bond strength of molecular astatine (At 2 ) and the hydration enthalpy of astatide (At − )". Journal of Mass Spectrometry. 59 (4). doi:10.1002/jms.5010. ISSN 1076-5174.
^ Watabe, Tadashi; Hosono, Makoto; Kinuya, Seigo; Yamada, Takahiro; Yanagida, Sachiko; Namba, Masao; Nakamura, Yoshihide (July 2021). "Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)". Annals of Nuclear Medicine. 35 (7): 753–766. doi:10.1007/s12149-021-01619-2. ISSN 1864-6433. PMC 8197710. PMID 33978932.
^ Ball, Philip (17 March 2020). "An affinity for astatine". Chemistry World. Retrieved 16 June 2023.
^ ^a ^b Y. Shirakami. "Preparation of [211At]-labeled sodium astatide (NaAt) by reducing with ascorbic acid for the treatment of thyroid cancer" (PDF). RIKEN Accel. Prog. Rep. 53: 171. Retrieved 16 June 2023.
^ "Breakthrough alpha-ray treatment of cancer without external radiation". EurekAlert!. Retrieved 16 June 2023.

[1] Burgers, Peter C.; Zeneyedpour, Lona; Luider, Theo M.; Holmes, John L. (2024). "Estimation of thermodynamic and physicochemical properties of the alkali astatides: On the bond strength of molecular astatine (At 2 ) and the hydration enthalpy of astatide (At − )". Journal of Mass Spectrometry. 59 (4). doi:10.1002/jms.5010. ISSN 1076-5174.

[2] Watabe, Tadashi; Hosono, Makoto; Kinuya, Seigo; Yamada, Takahiro; Yanagida, Sachiko; Namba, Masao; Nakamura, Yoshihide (July 2021). "Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)". Annals of Nuclear Medicine. 35 (7): 753–766. doi:10.1007/s12149-021-01619-2. ISSN 1864-6433. PMC 8197710. PMID 33978932.

[3] Ball, Philip (17 March 2020). "An affinity for astatine". Chemistry World. Retrieved 16 June 2023.

[shiri-4] Y. Shirakami. "Preparation of [211At]-labeled sodium astatide (NaAt) by reducing with ascorbic acid for the treatment of thyroid cancer" (PDF). RIKEN Accel. Prog. Rep. 53: 171. Retrieved 16 June 2023.

[5] "Breakthrough alpha-ray treatment of cancer without external radiation". EurekAlert!. Retrieved 16 June 2023.

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