Wikipedia

Solithromycin

Solithromycin (trade name Solithera) is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia[1] and other infections.[2]

Solithromycin
Clinical data
Trade namesSolithera
Other namesCEM-101; OP-1068
Routes of
administration		Oral, intravenous
ATC code
Legal status
Legal status
  • Under FDA and EMA review for approval
Identifiers
  • (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
CAS Number
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC43H65FN6O10
Molar mass845.023 g·mol−1
3D model (JSmol)
  • CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@](C(=O)O1)(C)F)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCn4cc(nn4)c5cccc(c5)N)C
  • InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1 ☒N
  • Key:IXXFZUPTQVDPPK-ZAWHAJPISA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Solithromycin exhibits excellent in vitro activity against a broad spectrum of Gram-positive respiratory tract pathogens,[3][4] including macrolide-resistant strains.[5] Solithromycin has activity against most common respiratory Gram-positive and fastidious Gram-negative pathogens,[6][7] and is being evaluated for its utility in treating gonorrhea.

Pre-clinical studies

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An in vivo pre-clinical study performed by Jeffrey Keelan done in sheep may provide a prophylactic approach for intrauterine infections during pregnancy. This study was carried out by administering solithromycin to pregnant sheep, resulting in effective concentrations greater than 30 ng/ml in the fetal plasma, maternal plasma and amniotic fluid. A single maternal dose maintained these concentrations for over 12 hours.[8]

Clinical trials

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  • May 2011: solithromycin is in a Phase 2 clinical trial for serious community-acquired bacterial pneumonia and in a Phase 1 clinical trial with an intravenous formulation.[9]
  • September 2011: solithromycin demonstrated comparable efficacy to levofloxacin with reduced adverse events in Phase 2 trial in people with community-acquired pneumonia[10]
  • January 2015: in a Phase 3 clinical trial for community-acquired bacterial pneumonia, solithromycin administered orally demonstrated statistical non-inferiority to the fluoroquinolone moxifloxacin.[11]
  • July 2015: patient enrollment for the second Phase 3 clinical trial (Solitaire IV) for community-acquired bacterial pneumonia was completed with results expected in Q4 2015.[12]
  • Oct 2015: IV to oral solithromycin demonstrated statistical non-inferiority to IV to oral moxifloxacin in adults with community-acquired bacterial pneumonia.[13]
  • July 2016: Cempra announced FDA acceptance of IV and oral formulations of Solithera (solithromycin) new drug applications for the treatment of community-acquired bacterial pneumonia.[14]

Structure

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X-ray crystallography studies have shown solithromycin, the first fluoroketolide in clinical development, has a third region of interactions with the bacterial ribosome,[15] as compared with two binding sites for other ketolides.

The only previously marketed ketolide, telithromycin, suffers from rare but serious side effects. Recent studies[16] have shown this to be likely due to the presence of the pyridine-imidazole group of the telithromycin side chain acting as an antagonist towards various nicotinic acetylcholine receptors. Solithromycin differs from telithromycin because the side chain does not significantly antagonize nicotinic acetylcholine receptors.[17] Instead of the pyridine-imidazole group used on telithromycin, this molecule has a triazole-phenylamine moiety.[citation needed]

Mechanism of action

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Solithromycin inhibits bacterial translation by binding to the 23S ribosomal RNA, preventing the offending bacteria from synthesizing proteins.[18]

Side effects

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During a clinical study some patients presented with elevated liver enzyme which may or may not be indicative of hepatotoxicity. This prompted the FDA Antimicrobial Drugs Advisory Committee to vote that the risk to the liver has not been adequately characterized and that further studies need to be conducted. To this extent, the FDA requests a 9,000 patient safety trial as well as restricting the drug.

Development

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In 2008, investigational new drug applications for solithromycin capsules and an intravenous formulation were submitted. From studies of pharmacokinetics, safety, and efficacy several issues were found. There is variable absorption which can result in subtherapeutic drug concentrations and even therapy failure. Additionally, there are significant drug-drug interactions affecting solithromycin concentrations as well the concentrations of the offending drugs. There is also a narrow therapeutic margin which can make this drug challenging to dose.[19]

Commercial aspects

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Cempra's general plan is to develop solithromycin develop products through late stage clinical trials and sell them to their hospital based sales force or through partnerships, which would need negotiations with larger pharmaceutical companies.[20] There are several manufacturing plants used such as Wockhardt Limited and Hospira Incorporated manufacturing facilities as well as Uquifa Laboratories, an alternative GMP facility.[21]

Intellectual property

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Due to the fact that bringing new products to the market takes a significant investment of time and money, companies place considerable importance on patent protection for new products. Solithromycin is a new chemical entity from the macrolide library of compounds that were licensed by Optimer. It is covered by a series of patents and patent applications which claim the composition of matter of solithromycin.[22] There are also patents surrounding the synthesis and purification of this substance. For example, patent EP3190122 A1 presents a novel, efficient route of synthesis that bypasses the need for chromatographic purification which saves time.[23]

References

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  1. ^ Reinert RR (June 2004). "Clinical efficacy of ketolides in the treatment of respiratory tract infections". The Journal of Antimicrobial Chemotherapy. 53 (6): 918–927. doi:10.1093/jac/dkh169. PMID 15117934.
  2. ^ "Solithromycin". Cempra. Archived from the original on 18 March 2012.
  3. ^ Woosley LN, Castanheira M, Jones RN (May 2010). "CEM-101 activity against Gram-positive organisms". Antimicrobial Agents and Chemotherapy. 54 (5): 2182–2187. doi:10.1128/AAC.01662-09. PMC 2863667. PMID 20176910.
  4. ^ Farrell DJ, Sader HS, Castanheira M, Biedenbach DJ, Rhomberg PR, Jones RN (June 2010). "Antimicrobial characterisation of CEM-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19A isolates". International Journal of Antimicrobial Agents. 35 (6): 537–543. doi:10.1016/j.ijantimicag.2010.01.026. PMID 20211548.
  5. ^ McGhee P, Clark C, Kosowska-Shick KM, Nagai K, Dewasse B, Beachel L, Appelbaum PC (January 2010). "In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms". Antimicrobial Agents and Chemotherapy. 54 (1): 230–238. doi:10.1128/AAC.01123-09. PMC 2798494. PMID 19884376.
  6. ^ Putnam SD, Castanheira M, Moet GJ, Farrell DJ, Jones RN (April 2010). "CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria". Diagnostic Microbiology and Infectious Disease. 66 (4): 393–401. doi:10.1016/j.diagmicrobio.2009.10.013. PMID 20022192.
  7. ^ Putnam SD, Sader HS, Farrell DJ, Biedenbach DJ, Castanheira M (January 2011). "Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci". International Journal of Antimicrobial Agents. 37 (1): 39–45. doi:10.1016/j.ijantimicag.2010.08.021. PMID 21075602.
  8. ^ Keelan JA, Kemp MW, Payne MS, Johnson D, Stock SJ, Saito M, et al. (4 November 2013). "Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model". Antimicrobial Agents and Chemotherapy. 58 (1): 447–454. doi:10.1128/AAC.01743-13. PMC 3910757. PMID 24189250.
  9. ^ "Intravenous (IV) Administration of Cempra Pharmaceutical's Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability in a Phase 1 Clinical Trial". 7 May 2011.
  10. ^ "Cempra antibiotic compound as effective, safer than levofloxacin". 15 Sep 2011.
  11. ^ http://investor.cempra.com/releasedetail.cfm?ReleaseID=889300. 4 Jan 2015 Archived 25 March 2015 at the Wayback Machine
  12. ^ http://investor.cempra.com/releasedetail.cfm?ReleaseID=920866. 7 July 2015 Archived 8 September 2015 at the Wayback Machine
  13. ^ "Cempra Announces Positive Topline Phase 3 Clinical Results for Intravenous Solithromycin in the Treatment of Community-Acquired Bacterial Pneumonia (NASDAQ:CEMP)". Archived from the original on 2016-01-05. Retrieved 2016-03-03.
  14. ^ "Cempra Announces FDA Acceptance of Solithera™ New Drug Applications in the Treatment of Community-Acquired Bacterial Pneumonia (NASDAQ:CEMP)". Archived from the original on 2016-07-09. Retrieved 2016-07-09.
  15. ^ Llano-Sotelo B, Dunkle J, Klepacki D, Zhang W, Fernandes P, Cate JH, Mankin AS (December 2010). "Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis". Antimicrobial Agents and Chemotherapy. 54 (12): 4961–4970. doi:10.1128/AAC.00860-10. PMC 2981243. PMID 20855725.
  16. ^ Bertrand D, Bertrand S, Neveu E, Fernandes P (December 2010). "Molecular characterization of off-target activities of telithromycin: a potential role for nicotinic acetylcholine receptors". Antimicrobial Agents and Chemotherapy. 54 (12): 5399–5402. doi:10.1128/AAC.00840-10. PMC 2981250. PMID 20855733.
  17. ^ Fernandes P, Martens E, Bertrand D, Pereira D (December 2016). "The solithromycin journey-It is all in the chemistry". Bioorganic & Medicinal Chemistry. 24 (24): 6420–6428. doi:10.1016/j.bmc.2016.08.035. PMID 27595539.
  18. ^ Owens B (March 2017). "Solithromycin rejection chills antibiotic sector". Nature Biotechnology. 35 (3): 187–188. doi:10.1038/nbt0317-187. PMID 28267725. S2CID 3648650.
  19. ^ "FDA Briefing Document Solithromycin Oral Capsule and Injection Meeting of the Antimicrobial Drugs Advisory Committee (AMDAC)" (PDF). www.fda.gov. Retrieved 31 October 2017.
  20. ^ "Cempra Annual Report". investor.cempra.com. Archived from the original on 2015-10-05. Retrieved 2017-10-30.
  21. ^ "Cempra Receives Complete Response Letter From FDA For Solithromycin NDAs (NASDAQ:CEMP)". investor.cempra.com. Archived from the original on 2017-07-04. Retrieved 2017-10-31.
  22. ^ "Cempra, Inc. - Annual Report". investor.cempra.com. Archived from the original on 2015-10-05. Retrieved 2017-10-30.
  23. ^ EP 3190122, "A novel synthetic pathway towards solithromycin and purification thereof", published 2017-07-12 
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