Spadolini may refer to:
- Giovanni Spadolini (1925–1994), Italian journalist, 44th Prime Minister of Italy, one-month Acting President of Italy upon the resignation of President Cossiga in 1992
- Spadolini I Cabinet, in office from 28 June 1981 to 23 August 1982
- Spadolini II Cabinet, in office from 23 August 1982 to 1 December 1982
- 15381 Spadolini, a minor planet discovered by V. Goretti in 1997
This disambiguation page lists articles associated with the title Spadolini.
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