The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold.[1] Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.[1]
| Spi-1 (PU.1) 5′ UTR regulatory element | |
|---|---|
 Predicted secondary structure and sequence conservation of Spi-1 | |
| Identifiers | |
| Symbol | Spi-1 |
| Rfam | RF00232 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| SO | SO:0000204 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ a b Hensold JO, Stratton CA, Barth D (July 1997). "The conserved 5′-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo". Nucleic Acids Research. 25 (14): 2869–2876. doi:10.1093/nar/25.14.2869. PMC 146829. PMID 9207037.
External links
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