Spla/ryanodine receptor domain and socs box containing 3

SplA/ryanodine receptor domain and SOCS box containing 3 is a protein that in humans is encoded by the SPSB3 gene.

SPRY domain
Identifiers
Symbol	SPRY
Pfam	PF00622
InterPro	IPR003877
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

SPSB3
Identifiers
Aliases	SPSB3, C16orf31, SSB3, Spla/ryanodine receptor domain and socs box containing 3
External IDs	OMIM: 611659; MGI: 1891471; HomoloGene: 12322; GeneCards: SPSB3; OMA:SPSB3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 1,776,712 bp End 1,793,700 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 25,105,617 bp End 25,111,126 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right hemisphere of cerebellum granulocyte skin of thigh skin of hip gastric mucosa endothelial cell right lobe of liver skin of abdomen apex of heart Top expressed in otic vesicle spermatocyte saccule spermatid otic placode lip seminiferous tubule right kidney esophagus thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component cytosol SCF ubiquitin ligase complex Biological process protein ubiquitination post-translational protein modification ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90864 79043 Ensembl ENSG00000162032 ENSMUSG00000024160 UniProt Q6PJ21 Q571F5 RefSeq (mRNA) NM_080861 NM_001324081 NM_001163750 NM_001163751 NM_027141 NM_001374602 NM_001400229 NM_001400231 NM_001400234 NM_001400235 NM_001400236 NM_001400237 NM_001400238 NM_001400240 RefSeq (protein) NP_001311010 NP_543137 NP_001157222 NP_001157223 NP_081417 NP_001361531 NP_001387158 NP_001387160 NP_001387163 NP_001387164 NP_001387165 NP_001387166 NP_001387167 NP_001387169 Location (UCSC) Chr 16: 1.78 – 1.79 Mb Chr 17: 25.11 – 25.11 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Eukaryotic Linear Motif resource motif class LIG_SPRY_1

Further reading

• Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa S (March 2011). "Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins". The Journal of Biological Chemistry. 286 (11): 9009–19. doi:10.1074/jbc.M110.190678. PMC 3058989. PMID 21199876.
• Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Wang D, Li Z, Messing EM, Wu G (April 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". The Journal of Biological Chemistry. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.
• Naukkarinen J, Surakka I, Pietiläinen KH, Rissanen A, Salomaa V, Ripatti S, Yki-Järvinen H, van Duijn CM, Wichmann HE, Kaprio J, Taskinen MR, Peltonen L (June 2010). Gibson G (ed.). "Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes". PLOS Genetics. 6 (6): e1000976. doi:10.1371/journal.pgen.1000976. PMC 2880558. PMID 20532202.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.