Spondin 2

Spondin 2, also known as mindin, is a protein that in humans is encoded by the SPON2 gene.

SPON2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D34
Identifiers
Aliases	SPON2, DIL-1, DIL1, M-SPONDIN, MINDIN, spondin 2
External IDs	OMIM: 605918; MGI: 1923724; HomoloGene: 40843; GeneCards: SPON2; OMA:SPON2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.3 Start 1,166,932 bp End 1,208,962 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B1 Start 33,355,528 bp End 33,375,799 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte decidua canal of the cervix body of uterus myometrium gastric mucosa left uterine tube beta cell right lobe of liver right uterine tube Top expressed in epithelium of lens cervix cornea esophagus lip efferent ductule duodenum sciatic nerve lumbar subsegment of spinal cord urinary bladder More reference expression data BioGPS n/a
Gene ontology Molecular function antigen binding lipopolysaccharide binding metal ion binding protein binding Cellular component extracellular region extracellular exosome extracellular space extracellular matrix Biological process mast cell mediated immunity positive regulation of macrophage cytokine production immune system process defense response to fungus axon guidance response to lipopolysaccharide cell adhesion defense response to virus defense response to bacterium positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production innate immune response cellular response to lipopolysaccharide opsonization induction of bacterial agglutination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10417 100689 Ensembl ENSG00000159674 ENSMUSG00000037379 UniProt Q9BUD6 Q8BMS2 RefSeq (mRNA) NM_012445 NM_001128325 NM_001199021 NM_133903 RefSeq (protein) NP_001121797 NP_001185950 NP_036577 NP_598664 Location (UCSC) Chr 4: 1.17 – 1.21 Mb Chr 5: 33.36 – 33.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Yan L, Wei X, Tang QZ, Feng J, Zhang Y, Liu C, Bian ZY, Zhang LF, Chen M, Bai X, Wang AB, Fassett J, Chen Y, He YW, Yang Q, Liu PP, Li H (October 2011). "Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling". Cardiovascular Research. 92 (1): 85–94. doi:10.1093/cvr/cvr159. PMC 3657538. PMID 21632881.
• Qian X, Li C, Pang B, Xue M, Wang J, Zhou J (2012). "Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker". PLOS ONE. 7 (5): e37225. Bibcode:2012PLoSO...737225Q. doi:10.1371/journal.pone.0037225. PMC 3352876. PMID 22615945.
• Feinstein Y, Klar A (June 2004). "The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities". The International Journal of Biochemistry & Cell Biology. 36 (6): 975–80. doi:10.1016/j.biocel.2004.01.002. PMID 15094111.
• Li Y, Cao C, Jia W, Yu L, Mo M, Wang Q, Huang Y, Lim JM, Ishihara M, Wells L, Azadi P, Robinson H, He YW, Zhang L, Mariuzza RA (February 2009). "Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule". The EMBO Journal. 28 (3): 286–97. doi:10.1038/emboj.2008.288. PMC 2637340. PMID 19153605.
• Liao CH, Yeh SC, Huang YH, Chen RN, Tsai MM, Chen WJ, Chi HC, Tai PJ, Liao CJ, Wu SM, Cheng WL, Pai LM, Lin KH (March 2010). "Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion". Endocrine-Related Cancer. 17 (1): 99–111. doi:10.1677/ERC-09-0050. PMID 19903741.
• Murakoshi M, Tanimoto M, Gohda T, Hagiwara S, Takagi M, Horikoshi S, Tomino Y (July 2011). "Mindin: a novel marker for podocyte injury in diabetic nephropathy". Nephrology, Dialysis, Transplantation. 26 (7): 2153–60. doi:10.1093/ndt/gfq708. PMID 21098016.
• Manda R, Kohno T, Matsuno Y, Takenoshita S, Kuwano H, Yokota J (October 1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display". Genomics. 61 (1): 5–14. doi:10.1006/geno.1999.5939. PMID 10512675.
• Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP (March 2006). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiological Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
• Kong A, Thorleifsson G, Stefansson H, Masson G, Helgason A, Gudbjartsson DF, Jonsdottir GM, Gudjonsson SA, Sverrisson S, Thorlacius T, Jonasdottir A, Hardarson GA, Palsson ST, Frigge ML, Gulcher JR, Thorsteinsdottir U, Stefansson K (March 2008). "Sequence variants in the RNF212 gene associate with genome-wide recombination rate". Science. 319 (5868): 1398–401. Bibcode:2008Sci...319.1398K. doi:10.1126/science.1152422. PMID 18239089. S2CID 5975476.