Spruce Pine may refer to:
- Pinus glabra, a tree found on the coastal plains of the southern United States, commonly known as the Spruce pine
- Spruce Pine, Alabama, a census-designated place in Franklin County, Alabama, United States
- Spruce Pine, North Carolina, a town in Mitchell County, North Carolina, United States
- Spruce Pine Mining District, a mine in North Carolina, United States
This disambiguation page lists articles associated with the title Spruce Pine.
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