The St. Francis River is a tributary of the Mississippi River in Missouri and Arkansas in the United States.
St. Francis River or Saint Francis River may also refer to:
- St. Francis River (Minnesota), a tributary of the Elk River in Minnesota in the United States
- Saint Francis River (Grenada) in Saint Andrew Parish on the east coast of Grenada
- Saint Francis River (Canada–United States), a tributary of the St. John River in Quebec, Maine, and New Brunswick which forms part of the Canada–United States border
See also
edit- Saint-François River, a tributary of the Saint Lawrence River in Quebec, Canada
- São Francisco River, the fourth longest Brazilian river and longest that starts runs entirely in Brazilian territory
- Lake Saint Francis (disambiguation)