St. Luke's Protestant Episcopal Church may refer to:
- in the United States
(by state)
- St. Luke's Protestant Episcopal Church (Sea Cliff, New York), a historic church in New York
- St. Luke's Protestant Episcopal Church (Seaford, Delaware), a historic church in Delaware
- St. Luke's Protestant Episcopal Church (Brooklyn, New York), also known as Church of St. Luke and St. Matthew, a historic church in New York