St. Mary Medical Center may refer to:
- St. Mary Medical Center (Long Beach), Long Beach, California
- St. Mary's Medical Center (San Francisco), San Francisco
- St. Mary Medical Center (Hobart), Hobart, Indiana
- St. Mary Medical Center (Langhorne), Langhorne, Pennsylvania
- Providence St. Mary Medical Center (Walla Walla), Walla Walla, Washington
- OSF St. Mary Medical Center, Galesburg, Illinois