St Cross (Saint Cross = Holy Cross) may refer to the following places in England:
- In Oxford
- Elsewhere
- St Cross, Llandaff in Cardiff
- St Cross Priory in the Isle of Wight
- St Cross Church, Appleton Thorn in Cheshire
- St Cross Church, Knutsford in Cheshire
- St Cross Church, Middleton in Leeds
- Hospital of St Cross and surrounding area of Winchester, Hampshire
- Hospital of St. Cross, Rugby, a hospital in Rugby, Warwickshire
- St Cross Catholic Primary School in Hoddesdon, Hertfordshire
- St Cross Chapel, Reigate, an Anglican chapel in a preserved windmill in Surrey
- Saint Cross Voivodeship in Poland