Stefanik or Štefánik may refer to:
- Milan Rastislav Štefánik (1880–1919), Slovak politician
- Armored train Štefánik, train used in Slovakia during World War II
- M. R. Štefánik Airport, airport in Bratislava, Slovakia
- Elise Stefanik (born 1984), American politician
- Marcin Stefanik (born 1987), Polish footballer
- Mike Stefanik (1958–2019), American stock car racing driver
- Samuel Štefánik (born 1991), Slovak footballer