Wikipedia

Stephanie Cragg

Stephanie J. Cragg is a British physiologist who is Professor of Neuroscience at the University of Oxford.[1] She holds a joint appointment[2][3] as Professor in the University Department of Physiology, Anatomy and Genetics and as a Fellow, Director of Studies and Tutor for Medicine at the college Christ Church, Oxford.[2]

Education and awards

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Cragg studied Natural Sciences at Clare College, University of Cambridge, followed by a DPhil in neuropharmacology at the University of Oxford Department of Pharmacology.[3] Her graduate supervisors were Baroness Professor Susan Greenfield (Oxford) and Dr Margaret Rice (New York University).[4] She received postdoctoral awards of an E.P. Abraham Junior Research Fellowship at St. Cross College, an E.P. Abraham Research Fellowship at Keble College, a Beit Memorial Fellowship and then a Paton Research Fellowship.[3]

Research

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Her work focusses on understanding the functioning in health and disease of the brain circuits and cell types that are dysregulated in Parkinson's disease, addictions and other neurological and neuropsychiatric disorders.[2][3] This work focusses particularly on the regulation of dopaminergic transmission.

Cragg's work includes the study of how dopamine release in the striatum is regulated by other neuronal pathways and neuromodulators, including the neurotransmitters acetylcholine, GABA, adenosine, and dysregulation in Parkinson's disease.[5][6] Her most cited work relates to the axonal regulation of dopamine transmission by acetylcholine, cholinergic interneurons and nicotinic acetylcholine receptors (nAChRs).[7][8]

Scientific leadership

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Scientific journals

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  • Addiction Neuroscience[9]
  • ACS Chemical Neuroscience[10]
  • npj Parkinson's Disease[11]

Societies

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Engagement with scientific societies include:

  • President-Elect of the International Society for Monitoring Molecules in Neuroscience (2022-2024)[12]
  • College of Experts for Parkinson's UK[13]

Keynote lectures

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  • EJN Special Feature Plenary Lecture, FENS Forum 2018, Berlin, Germany[14]
  • Keynote Speaker, ViDA 2020 - Virtual Dopamine Conference[15]
  • Swedish Basal Ganglia Society 2022[16]
  • Plenary Lecture, Dopamine 2022, Montreal, Canada[17]

References

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  1. ^ "Recognition of Distinction: Successful applicants 2014" Archived 16 September 2015 at the Wayback Machine, The University of Oxford Gazette, no. 5076, 6 November 2014. Retrieved 20 November 2016.
  2. ^ a b c "Professor Stephanie Cragg | Christ Church, University of Oxford". www.chch.ox.ac.uk. Retrieved 18 October 2023.
  3. ^ a b c d "Stephanie Cragg". www.dpag.ox.ac.uk. Retrieved 18 October 2023.
  4. ^ Helmreich, Dana L. (July 2018). "Profiles of Women in Science: Prof. Stephanie Cragg of the University of Oxford, Oxford, UK". European Journal of Neuroscience. 48 (2): 1723–1727. doi:10.1111/ejn.14058. PMID 29968289. Retrieved 18 October 2023.
  5. ^ Roberts, Bradley M.; Doig, Natalie M.; Brimblecombe, Katherine R.; Lopes, Emanuel F.; Siddorn, Ruth E.; Threlfell, Sarah; Connor-Robson, Natalie; Bengoa-Vergniory, Nora; Pasternack, Nicholas; Wade-Martins, Richard; Magill, Peter J.; Cragg, Stephanie J. (2 October 2020). "GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model". Nature Communications. 11 (1): 4958. Bibcode:2020NatCo..11.4958R. doi:10.1038/s41467-020-18247-5. PMC 7532441. PMID 33009395.
  6. ^ Cramb, Kaitlyn M L; Beccano-Kelly, Dayne; Cragg, Stephanie J; Wade-Martins, Richard (1 August 2023). "Impaired dopamine release in Parkinson's disease". Brain. 146 (8): 3117–3132. doi:10.1093/brain/awad064. PMC 10393405. PMID 36864664.
  7. ^ Threlfell, Sarah; Lalic, Tatjana; Platt, Nicola J.; Jennings, Katie A.; Deisseroth, Karl; Cragg, Stephanie J. (July 2012). "Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons". Neuron. 75 (1): 58–64. doi:10.1016/j.neuron.2012.04.038. PMID 22794260.
  8. ^ Rice, Margaret E; Cragg, Stephanie J (June 2004). "Nicotine amplifies reward-related dopamine signals in striatum". Nature Neuroscience. 7 (6): 583–584. doi:10.1038/nn1244. PMID 15146188.
  9. ^ "Addiction Neuroscience | Journal | ScienceDirect.com by Elsevier". www.sciencedirect.com.
  10. ^ "Editors & Editorial Board". ACS Publications.
  11. ^ "npj Parkinson's Disease". Nature. 10 July 2023. Retrieved 18 October 2023.
  12. ^ "About". MMiN. Retrieved 18 October 2023.
  13. ^ "Parkinson's UK College of Experts". Parkinson's UK. Retrieved 18 October 2023.
  14. ^ "Feature Plenary Lecture, FENS Forum 2018".
  15. ^ "Speakers". VIDA 2020.
  16. ^ "Webinar Recordings".
  17. ^ "Plenary Lectures".
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