Sushi domain containing 2

Sushi domain containing 2 is a protein located in the plasma membrane that, in humans, is encoded by the SUSD2 gene.

SUSD2
Identifiers
Aliases	SUSD2, BK65A6.2, sushi domain containing 2, W5C5
External IDs	OMIM: 615825; MGI: 1918983; HomoloGene: 10481; GeneCards: SUSD2; OMA:SUSD2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.23 Start 24,181,487 bp End 24,189,106 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 75,472,540 bp End 75,479,842 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum lower lobe of lung right lung upper lobe of lung upper lobe of left lung right coronary artery popliteal artery tibial arteries left coronary artery skin of arm Top expressed in epithelium of lens intestinal villus right kidney facial motor nucleus umbilical cord skin of external ear human kidney lacrimal gland proximal tubule lip More reference expression data BioGPS n/a
Gene ontology Molecular function scavenger receptor activity polysaccharide binding protein binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane Biological process negative regulation of cell division receptor-mediated endocytosis immune response negative regulation of cell cycle G1/S phase transition vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56241 71733 Ensembl ENSG00000099994 ENSMUSG00000006342 UniProt Q9UGT4 Q9DBX3 RefSeq (mRNA) NM_019601 NM_001162913 NM_027890 RefSeq (protein) NP_062547 NP_001156385 NP_082166 Location (UCSC) Chr 22: 24.18 – 24.19 Mb Chr 10: 75.47 – 75.48 Mb PubMed search
Wikidata
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It's involved in the negative regulation of cell cycle G1/S phase transition and cell division, and possibly involved in maintaining cell state. It also regulates central nervous system (CNS) development.

Further reading

• Watson AP, Evans RL, Egland KA (2013). "Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis". Mol. Cancer Res. 11 (1): 74–85. doi:10.1158/1541-7786.MCR-12-0501-T. PMC 4426260. PMID 23131994.
• Deng M, Wei L, Zuo X, Tian Y, Xie F, Hu P, Zhu C, Yu F, Meng Y, Wang H, Zhang F, Ma H, Ye R, Cheng H, Du J, Dong W, Zhou S, Wang C, Wang Y, Wang J, Chen X, Sun Z, Zhou N, Jiang Y, Liu X, Li X, Zhang N, Liu N, Guan Y, Han Y, Han Y, Lv X, Fu Y, Yu H, Xi C, Xie D, Zhao Q, Xie P, Wang X, Zhang Z, Shen L, Cui Y, Yin X, Cheng H, Liang B, Zheng X, Lee TM, Chen G, Zhou F, Veldink JH, Robberecht W, Landers JE, Andersen PM, Al-Chalabi A, Shaw C, Liu C, Tang B, Xiao S, Robertson J, Zhang F, van den Berg LH, Sun L, Liu J, Yang S, Ju X, Wang K, Zhang X (2013). "Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis". Nat. Genet. 45 (6): 697–700. doi:10.1038/ng.2627. PMID 23624525. S2CID 7924012.
• An R, Xi J, Yang X, Yao X, Xu Y (2015). "No evidence of association between polymorphisms in four genes and sporadic amyotrophic lateral sclerosis in Han Chinese". Amyotroph Lateral Scler Frontotemporal Degener. 16 (3–4): 245–8. doi:10.3109/21678421.2014.999790. PMID 25677198. S2CID 1726623.
• Cheng Y, Wang X, Wang P, Li T, Hu F, Liu Q, Yang F, Wang J, Xu T, Han W (2016). "SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer". Tumour Biol. 37 (7): 9919–30. doi:10.1007/s13277-015-4734-y. PMID 26815503. S2CID 5782134.