Suzetrigine (developmental code name VX-548) is a non-opioid, small-molecule analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling pathways in the peripheral nervous system.[1][2] It is being developed by Vertex Pharmaceuticals and has completed two phase 3 clinical trials.[1][3]
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| Other names | VX-548 |
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| Formula | C21H20F5N3O4 |
| Molar mass | 473.400 g·mol−1 |
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Vertex Pharmaceuticals announced in January 2024 that suzetrigine successfully met several endpoints in its phase 3 trials. The drug relieved moderate-to-severe post-surgical pain. The company hopes that the drug, which operates on peripheral nerves, will avoid the addictive potential of opioids.[3][4]
Vertex Pharmaceuticals plans to submit a New Drug Application (NDA) to the US Food and Drug Administration (FDA) by mid-2024 seeking a broad label for moderate-to-severe acute pain. Suzetrigine has already secured FDA Breakthrough Therapy and Fast Track designations for acute pain.[3]
Vertex Pharmaceuticals also plans to seek a broad label for peripheral neuropathic pain, citing positive phase 2 results in painful diabetic peripheral neuropathy (DPN).[3] The drug is additionally under development for the treatment of radiculopathy and pain in other contexts.[1]
See also
editReferences
edit- ^ a b c "Suzetrigine - Vertex Pharmaceuticals". AdisInsight. 19 August 2024. Retrieved 24 August 2024.
- ^ Jones, Jim; Correll, Darin J.; Lechner, Sandra M.; Jazic, Ina; Miao, Xiaopeng; Shaw, David; Simard, Christopher; Osteen, Jeremiah D.; Hare, Brian; Beaton, Alina; Bertoch, Todd; Buvanendran, Asokumar; Habib, Ashraf S.; Pizzi, Lois J.; Pollak, Richard A.; Weiner, Scott G.; Bozic, Carmen; Negulescu, Paul; White, Paul F. (3 August 2023). "Selective Inhibition of NaV1.8 with VX-548 for Acute Pain". The New England Journal of Medicine. 389 (5): 393–405. doi:10.1056/NEJMoa2209870. ISSN 1533-4406. PMID 37530822. S2CID 260377748.
- ^ a b c d Vertex Pharmaceuticals Incorporated Vertex Announces Positive Results From the VX-548 Phase 3 Program for the Treatment of Moderate-to-Severe Acute Pain. Press Release, Jan 30, 2024.
- ^ Kolata, Gina (30 January 2024). "Experimental Drug Cuts Off Pain at the Source, Company Says". The New York Times. Retrieved 31 January 2024.