Sweetwater Creek may refer to:
- Sweetwater Creek (novel), a novel by Anne Rivers Siddons
- Sweetwater Creek, Florida, an unincorporated community in Hillsborough County, Florida
- Sweetwater Creek (Chattahoochee River), Georgia
- Sweetwater Creek State Park, in Douglas County, Georgia
- Sweetwater Creek (Echeconnee Creek tributary), Georgia
- Sweetwater Creek (Flint River tributary), Georgia
- Sweetwater Creek (Logan Creek), a stream in Missouri
- Sweetwater Creek (Comanche County, Texas)
- Sweetwater Creek (Gray County, Texas)
- Sweetwater Creek (Nolan County, Texas), namesake of Sweetwater, Texas
- Sweetwater Creek (Wise County, Texas)
- Sweetwater Creek (Tennessee River), tributary to the Tennessee River at Loudon, Tennessee
- Sweetwater Creek in Frankston, Victoria, Australia