Sydney Lee or Sidney Lee may refer to:
- Sydney Lee (engraver) (1866–1949), British wood engraver
- Sydney Lee (snooker player) (1911–1986), English billiards and snooker player
- Sydney Smith Lee (1802–1869), American naval officer
- Sidney Lee (1859–1926), English biographer, writer and critic
- Sidney Lee (1979–2022), Danish television personality and presenter