Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.[5][6]

TACC2
Identifiers
AliasesTACC2, AZU-1, ECTACC, transforming acidic coiled-coil containing protein 2
External IDsOMIM: 605302; MGI: 1928899; HomoloGene: 5087; GeneCards: TACC2; OMA:TACC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004468
NM_021314
NM_206856
NM_001347637

RefSeq (protein)

NP_001004468
NP_001334566
NP_067289
NP_996738

Location (UCSC)Chr 10: 121.99 – 122.25 MbChr 7: 130.18 – 130.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138162Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030852Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH (Apr 2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476. S2CID 22590391.
  6. ^ a b "Entrez Gene: TACC2 transforming, acidic coiled-coil containing protein 2".

Further reading

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