This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[ 5]
Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium .[ 6]
^ a b c ENSG00000273086, ENSG00000121381 GRCh38: Ensembl release 89: ENSG00000273713, ENSG00000273086, ENSG00000121381 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors" . Cell . 100 (6): 693–702. doi :10.1016/S0092-8674(00)80705-9 PMID 10761934 . S2CID 14604586 . ^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature . 404 (6778): 601–4. Bibcode :2000Natur.404..601M . doi :10.1038/35007072 . PMID 10766242 . S2CID 4336913 . ^ a b "Entrez Gene: TAS2R9 taste receptor, type 2, member 9" .^ Allen AL, McGeary JE, Knopik VS, Hayes JE (2013). "Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31" . Chem. Senses . 38 (5): 379–89. doi :10.1093/chemse/bjt017 . PMC 3657735 PMID 23599216 .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
