TC-2216

TC-2216
Identifiers
	IUPAC name 8-pyridin-3-yl-1,8-diazaspiro[4.4]nonane;
CAS Number	646055-67-6 ;
PubChem CID	10176607;
ChemSpider	8352112;
UNII	J2T94PE2HD;
CompTox Dashboard (EPA)	DTXSID00436446 ;
Chemical and physical data
Formula	C12H17N3
Molar mass	203.289 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N1CCCC1(CC2)CN2c3cnccc3;
	InChI InChI=1S/C12H17N3/c1-3-11(9-13-6-1)15-8-5-12(10-15)4-2-7-14-12/h1,3,6,9,14H,2,4-5,7-8,10H2; Key:NXIPMBQVNTWEEX-UHFFFAOYSA-N;
	(verify)

TC-2216 is a drug developed by Targacept which acts as a partial agonist at neural nicotinic acetylcholine receptors and was researched for the treatment of anxiety and depression.^[1] It was unsuccessful as a therapeutic but is still used in pharmacological research as an alpha4beta2-selective antagonist.^[2]

References

^ Romanelli MN, Gratteri P, Guandalini L, Martini E, Bonaccini C, Gualtieri F (June 2007). "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem. 2 (6): 746–67. doi:10.1002/cmdc.200600207. PMID 17295372. S2CID 34763474.
^ Lippiello PM, Beaver JS, Gatto GJ, James JW, Jordan KG, Traina VM, Xie J, Bencherif M (2008). "TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity". CNS Neuroscience & Therapeutics. 14 (4): 266–77. doi:10.1111/j.1755-5949.2008.00054.x. PMC 6494058. PMID 19040552.

Identifiers

IUPAC name 8-pyridin-3-yl-1,8-diazaspiro[4.4]nonane
CAS Number	646055-67-6^Y
PubChem CID	10176607
ChemSpider	8352112
UNII	J2T94PE2HD
CompTox Dashboard (EPA)	DTXSID00436446
Chemical and physical data
Formula	C₁₂H₁₇N₃
Molar mass	203.289 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N1CCCC1(CC2)CN2c3cnccc3
InChI InChI=1S/C12H17N3/c1-3-11(9-13-6-1)15-8-5-12(10-15)4-2-7-14-12/h1,3,6,9,14H,2,4-5,7-8,10H2 Key:NXIPMBQVNTWEEX-UHFFFAOYSA-N
(verify)