TECR

TECR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DZJ
Identifiers
Aliases	TECR, GPSN2, MRT14, SC2, TER, trans-2,3-enoyl-CoA reductase
External IDs	OMIM: 610057; MGI: 1915408; HomoloGene: 36231; GeneCards: TECR; OMA:TECR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,565,980 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,334,600 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; left testis; ; right testis; ; skin of abdomen; ; skin of leg; ; C1 segment; ; minor salivary glands; ; muscle of thigh; ; right adrenal cortex; ; right frontal lobe;
	Top expressed in
	central gray substance of midbrain; ; cerebellar cortex; ; cerebellar vermis; ; dorsal tegmental nucleus; ; ventromedial nucleus; ; medial vestibular nucleus; ; primary visual cortex; ; supraoptic nucleus; ; lobe of cerebellum; ; pontine nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; protein binding; very-long-chain-acyl-CoA dehydrogenase activity; oxidoreductase activity; very-long-chain enoyl-CoA reductase activity;
Cellular component	cytoplasm; integral component of membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; endoplasmic reticulum; nucleus; membrane;
Biological process	fatty acid elongation; fatty acid biosynthetic process; long-chain fatty-acyl-CoA biosynthetic process; very long-chain fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolism; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9524
	106529
	ENSG00000099797
	ENSMUSG00000031708
	Q9NZ01
	Q9CY27
	NM_004868; NM_138501; NM_001321170
	NM_027179; NM_134118
	NP_001308099; NP_612510
	NP_081455; NP_598879
	Wikidata
View/Edit Human	View/Edit Mouse

Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.^[5]

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.^[5]

Clinical relevance

Mutations in this gene have been shown to cause non-syndromic mental retardation.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099797 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031708 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Trans-2,3-enoyl-CoA reductase". Retrieved 2011-12-30.
^ Çalışkan M, Chong JX, Uricchio L, Anderson R, Chen P, Sougnez C, Garimella K, Gabriel SB, dePristo MA, Shakir K, Matern D, Das S, Waggoner D, Nicolae DL, Ober C (April 2011). "Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13". Hum. Mol. Genet. 20 (7): 1285–9. doi:10.1093/hmg/ddq569. PMC 3115579. PMID 21212097.

Moon, Y. -A.; Horton, J. D. (2002). "Identification of Two Mammalian Reductases Involved in the Two-carbon Fatty Acyl Elongation Cascade". Journal of Biological Chemistry. 278 (9): 7335–7343. doi:10.1074/jbc.M211684200. PMID 12482854.
Hashmi, G.; Shariff, T.; Seul, M.; Vissavajjhala, P.; Hue-Roye, K.; Charles-Pierre, D.; Lomas-Francis, C.; Chaudhuri, A.; Reid, M. E. (2005). "A flexible array format for large-scale, rapid blood group DNA typing". Transfusion. 45 (5): 680–688. doi:10.1111/j.1537-2995.2005.04362.x. PMID 15847654. S2CID 40662473.
Lehner, R.; Kuksis, A. (1996). "Biosynthesis of triacylglycerols". Progress in Lipid Research. 35 (2): 169–201. doi:10.1016/0163-7827(96)00005-7. PMID 8944226.
Mao, M.; Fu, G.; Wu, J. S.; Zhang, Q. H.; Zhou, J.; Kan, L. X.; Huang, Q. H.; He, K. L.; Gu, B. W.; Han, Z. -G.; Shen, Y.; Gu, J.; Yu, Y. -P.; Xu, S. -H.; Wang, Y. -X.; Chen, S. -J.; Chen, Z. (1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–8180. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099797 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031708 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Trans-2,3-enoyl-CoA reductase". Retrieved 2011-12-30.

[pmid21212097-6] Çalışkan M, Chong JX, Uricchio L, Anderson R, Chen P, Sougnez C, Garimella K, Gabriel SB, dePristo MA, Shakir K, Matern D, Das S, Waggoner D, Nicolae DL, Ober C (April 2011). "Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13". Hum. Mol. Genet. 20 (7): 1285–9. doi:10.1093/hmg/ddq569. PMC 3115579. PMID 21212097.

[5]

[1]

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[6]

TECR

Clinical relevance

References

Further reading