TENC1

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.

TNS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DKQ, 2KNO, 2L6K, 2LOZ, 3HQC
Identifiers
Aliases	TNS2, C1-TEN, C1TEN, TENC1, tensin 2
External IDs	OMIM: 607717; MGI: 2387586; HomoloGene: 37077; GeneCards: TNS2; OMA:TNS2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 53,046,969 bp End 53,064,379 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F2|15 57.29 cM Start 102,008,848 bp End 102,024,836 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastric mucosa tibial nerve canal of the cervix right ovary left uterine tube body of uterus left ovary right lung right lobe of thyroid gland Top expressed in ankle joint muscle of thigh tunica media of zone of aorta right lung right lung lobe lip brown adipose tissue myocardium of ventricle ankle left lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase binding phosphoprotein phosphatase activity protein binding hydrolase activity metal ion binding Cellular component cell junction plasma membrane intracellular anatomical structure membrane focal adhesion Biological process protein dephosphorylation collagen metabolic process intracellular signal transduction multicellular organismal homeostasis response to muscle activity cellular homeostasis kidney development negative regulation of cell population proliferation multicellular organism growth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23371 209039 Ensembl ENSG00000111077 ENSMUSG00000037003 UniProt Q63HR2 Q8CGB6 RefSeq (mRNA) NM_015319 NM_170754 NM_198316 NM_153533 NM_001355636 RefSeq (protein) NP_056134 NP_736610 NP_938072 NP_705761 NP_001342565 Location (UCSC) Chr 12: 53.05 – 53.06 Mb Chr 15: 102.01 – 102.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

Interactions

TENC1 has been shown to interact with AXL receptor tyrosine kinase.

Further reading

• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Chen H, Duncan IC, Bozorgchami H, Lo SH (2002). "Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 733–8. Bibcode:2002PNAS...99..733C. doi:10.1073/pnas.022518699. PMC 117374. PMID 11792844.
• Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Calderwood DA, Fujioka Y, de Pereda JM, et al. (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272–7. Bibcode:2003PNAS..100.2272C. doi:10.1073/pnas.262791999. PMC 151330. PMID 12606711.
• Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling". J. Biol. Chem. 279 (28): 29325–35. doi:10.1074/jbc.M311144200. PMID 15117958.
• Hafizi S, Ibraimi F, Dahlbäck B (2006). "C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration". FASEB J. 19 (8): 971–3. doi:10.1096/fj.04-2532fje. PMID 15817639. S2CID 42601912.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Yam JW, Ko FC, Chan CY, et al. (2006). "Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma". Hepatology. 44 (4): 881–90. doi:10.1002/hep.21339. PMID 17006924. S2CID 10376927.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Tensin-2