TGS1

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.

TGS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EGI, 3GDH
Identifiers
Aliases	TGS1, NCOA6IP, PIMT, PIPMT, trimethylguanosine synthase 1
External IDs	OMIM: 606461; MGI: 2151797; HomoloGene: 32608; GeneCards: TGS1; OMA:TGS1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q12.1 Start 55,773,446 bp End 55,826,445 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 A1|4 1.99 cM Start 3,574,875 bp End 3,616,619 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii oocyte secondary oocyte Achilles tendon nipple tail of epididymis pylorus internal globus pallidus renal medulla corpus epididymis Top expressed in tail of embryo condyle cumulus cell genital tubercle ureter primitive streak pineal gland renal corpuscle fossa abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity RNA trimethylguanosine synthase activity protein binding RNA methyltransferase activity Cellular component cytoplasm Cajal body nucleoplasm nucleolus small nuclear ribonucleoprotein complex nucleus extracellular space cytosol Biological process regulation of transcription, DNA-templated transcription, DNA-templated spliceosomal snRNP assembly methylation 7-methylguanosine RNA capping 7-methylguanosine cap hypermethylation ribonucleoprotein complex biogenesis RNA methylation regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 96764 116940 Ensembl ENSG00000137574 ENSMUSG00000028233 UniProt Q96RS0 Q923W1 RefSeq (mRNA) NM_024831 NM_001317902 NM_001363184 NM_054089 RefSeq (protein) NP_001304831 NP_079107 NP_001350113 NP_473430 Location (UCSC) Chr 8: 55.77 – 55.83 Mb Chr 4: 3.57 – 3.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TGS1 has been shown to interact with:

• CREB-binding protein, and
• EED,
• EP300,
• MED1, and
• NCOA6.

Further reading

• Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.
• Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, Bordonné R, Bertrand E (2002). "Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments". EMBO J. 21 (11): 2736–45. doi:10.1093/emboj/21.11.2736. PMC 126019. PMID 12032086.
• Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.
• Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. Bibcode:2002PNAS...9911836S. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
• Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG (2002). "Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX". Blood. 100 (6): 2123–31. doi:10.1182/blood-2002-02-0513. PMID 12200376.
• Mouaikel J, Narayanan U, Verheggen C, Matera AG, Bertrand E, Tazi J, Bordonné R (2004). "Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron". EMBO Rep. 4 (6): 616–22. doi:10.1038/sj.embor.embor863. PMC 1319203. PMID 12776181.
• Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/S0006-291X(03)01514-6. PMID 12943661.
• Watkins NJ, Lemm I, Ingelfinger D, Schneider C, Hossbach M, Urlaub H, Lührmann R (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. hdl:11858/00-001M-0000-0012-EB89-8. PMID 15574333.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.