TJP3

Tight junction protein ZO-3 is a protein that in humans is encoded by the TJP3 gene.

TJP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KFV
Identifiers
Aliases	TJP3, ZO-3, ZO3, tight junction protein 3
External IDs	OMIM: 612689; MGI: 1351650; HomoloGene: 8458; GeneCards: TJP3; OMA:TJP3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 3,708,362 bp End 3,750,813 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 81,109,041 bp End 81,127,415 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right uterine tube olfactory zone of nasal mucosa left testis right testis nasal epithelium buccal mucosa cell epithelium of bronchus bronchial epithelial cell rectum Top expressed in crypt of lieberkuhn of small intestine left colon ileum epithelium of stomach jejunum intestinal villus duodenum mucous cell of stomach transitional epithelium of urinary bladder pyloric antrum More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 27134 27375 Ensembl ENSG00000105289 ENSMUSG00000034917 UniProt O95049 Q9QXY1 RefSeq (mRNA) NM_014428 NM_001267560 NM_001267561 NM_001282095 NM_001282096 NM_013769 RefSeq (protein) NP_001254489 NP_001254490 n/a Location (UCSC) Chr 19: 3.71 – 3.75 Mb Chr 10: 81.11 – 81.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TJP3 has been shown to interact with tight junction protein 1.

Further reading

• Roh MH, Liu CJ, Laurinec S, Margolis B (July 2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions". The Journal of Biological Chemistry. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
• Kausalya PJ, Reichert M, Hunziker W (September 2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells". FEBS Letters. 505 (1): 92–6. doi:10.1016/S0014-5793(01)02786-7. PMID 11557048. S2CID 13489358.
• Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (December 1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". The Journal of Cell Biology. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
• Wittchen ES, Haskins J, Stevenson BR (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". The Journal of Biological Chemistry. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.
• Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR (April 1998). "ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin". The Journal of Cell Biology. 141 (1): 199–208. doi:10.1083/jcb.141.1.199. PMC 2132714. PMID 9531559.