TMX4

Thioredoxin-related transmembrane protein 4 also known as thioredoxin domain-containing protein 13 is a protein that in humans is encoded by the TMX4 gene.

TMX4
Identifiers
Aliases	TMX4, DJ971N18.2, PDIA14, TXNDC13, thioredoxin related transmembrane protein 4
External IDs	OMIM: 616766; MGI: 106558; HomoloGene: 10901; GeneCards: TMX4; OMA:TMX4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20p12.3 Start 7,977,346 bp End 8,019,805 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 F2- F3|2 65.66 cM Start 134,436,105 bp End 134,486,065 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Brodmann area 23 seminal vesicula tail of epididymis Epithelium of choroid plexus caput epididymis endothelial cell cardiac muscle tissue of right atrium parotid gland middle temporal gyrus Top expressed in dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus arcuate nucleus ventromedial nucleus lateral hypothalamus median eminence suprachiasmatic nucleus ventral tegmental area mammillary body anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein disulfide isomerase activity Cellular component membrane integral component of membrane endoplasmic reticulum Biological process protein folding response to endoplasmic reticulum stress cell redox homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56255 52837 Ensembl ENSG00000125827 ENSMUSG00000034723 UniProt Q9H1E5 Q8C0L0 RefSeq (mRNA) NM_021156 NM_029148 RefSeq (protein) NP_066979 NP_083424 Location (UCSC) Chr 20: 7.98 – 8.02 Mb Chr 2: 134.44 – 134.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.