Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.[5]

TNFRSF19
Identifiers
AliasesTNFRSF19, TAJ, TAJ-alpha, TRADE, TROY, tumor necrosis factor receptor superfamily member 19, TNF receptor superfamily member 19
External IDsOMIM: 606122; MGI: 1352474; HomoloGene: 8481; GeneCards: TNFRSF19; OMA:TNFRSF19 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204458
NM_001204459
NM_018647
NM_148957
NM_001354985

NM_001164155
NM_013869

RefSeq (protein)

NP_001191387
NP_001191388
NP_061117
NP_683760
NP_001341914

NP_001157627
NP_038897

Location (UCSC)Chr 13: 23.57 – 23.68 MbChr 14: 61.2 – 61.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127863Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060548Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.