Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.[5]

TNFSF12-TNFSF13
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesTNFSF12-TNFSF13, TWE-PRIL, TNFSF12-TNFSF13 readthrough
External IDsMGI: 3845075; HomoloGene: 123930; GeneCards: TNFSF12-TNFSF13; OMA:TNFSF12-TNFSF13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_172089

NM_001034097
NM_001034098
NM_001159503

RefSeq (protein)

NP_003800

n/a

Location (UCSC)Chr 17: 7.55 – 7.56 MbChr 11: 69.57 – 69.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the tumor necrosis factor superfamily (TNFSF). It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of the family member 12 fused to the C-terminal domain of the family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of the family member 13 at the cell surface. It stimulates cycling in T-lymphoma and B-lymphoma cell lines. The mRNA transcript is expressed and translated in primary T cells and monocytes.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000248871Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018752Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13".

Further reading

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