TNIP3 (gene)

TNFAIP3 interacting protein 3 is a protein that in humans is encoded by the TNIP3 gene.

TNIP3
Identifiers
Aliases	TNIP3, ABIN-3, LIND, TNFAIP3 interacting protein 3
External IDs	OMIM: 608019; MGI: 3041165; HomoloGene: 47979; GeneCards: TNIP3; OMA:TNIP3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q27 Start 121,131,408 bp End 121,227,466 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C1 Start 65,502,297 bp End 65,611,024 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad epithelium of colon appendix lymph node gallbladder stromal cell of endometrium upper lobe of left lung prefrontal cortex tonsil Top expressed in secondary oocyte zygote primary oocyte embryo colon white adipose tissue thymus ileum lung heart More reference expression data BioGPS n/a
Gene ontology Molecular function polyubiquitin modification-dependent protein binding protein binding protein kinase binding Cellular component cytosol cytoplasm Biological process inflammatory response toll-like receptor 4 signaling pathway MyD88-independent toll-like receptor signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling cellular response to lipopolysaccharide protein deubiquitination positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79931 414084 Ensembl ENSG00000050730 ENSMUSG00000044162 UniProt Q96KP6 n/a RefSeq (mRNA) NM_001128843 NM_001244764 NM_024873 NM_001001495 RefSeq (protein) NP_001122315 NP_001231693 NP_079149 n/a Location (UCSC) Chr 4: 121.13 – 121.23 Mb Chr 6: 65.5 – 65.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Wullaert A, Verstrepen L, Van Huffel S, Adib-Conquy M, Cornelis S, Kreike M, Haegman M, El Bakkouri K, Sanders M, Verhelst K, Carpentier I, Cavaillon JM, Heyninck K, Beyaert R (January 2007). "LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation". J. Biol. Chem. 282 (1): 81–90. doi:10.1074/jbc.M607481200. PMID 17088249.
• Weaver BK, Bohn E, Judd BA, Gil MP, Schreiber RD (July 2007). "ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions". Mol. Cell. Biol. 27 (13): 4603–16. doi:10.1128/MCB.00223-07. PMC 1951479. PMID 17485448.
• Verstrepen L, Adib-Conquy M, Kreike M, Carpentier I, Adrie C, Cavaillon JM, Beyaert R (2008). "Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB". J. Cell. Mol. Med. 12 (1): 316–29. doi:10.1111/j.1582-4934.2007.00187.x. PMC 3823492. PMID 18081698.
• Verstrepen L, Carpentier I, Verhelst K, Beyaert R (July 2009). "ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling". Biochem. Pharmacol. 78 (2): 105–14. doi:10.1016/j.bcp.2009.02.009. PMID 19464428.
• Folco EJ, Rocha VZ, López-Ilasaca M, Libby P (September 2009). "Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10". J. Biol. Chem. 284 (38): 25569–75. doi:10.1074/jbc.M109.019786. PMC 2757958. PMID 19617629.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Igarashi H, Yahagi A, Saika T, Hashimoto J, Tomita T, Yoshikawa H, Ishihara K (January 2012). "A pro-inflammatory role for A20 and ABIN family proteins in human fibroblast-like synoviocytes in rheumatoid arthritis". Immunol. Lett. 141 (2): 246–53. doi:10.1016/j.imlet.2011.10.011. PMID 22093807.