TOPORS

E3 ubiquitin-protein ligase Topors is an enzyme that in humans is encoded by the TOPORS gene.

TOPORS
Identifiers
Aliases	TOPORS, LUN, P53BP3, RP31, TP53BPL, TOP1 binding arginine/serine rich protein, TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
External IDs	OMIM: 609507; MGI: 2146189; HomoloGene: 4237; GeneCards: TOPORS; OMA:TOPORS - orthologs
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 40,259,601 bp End 40,269,850 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon sperm corpus epididymis caput epididymis trabecular bone jejunal mucosa seminal vesicula oral cavity bone marrow Top expressed in primitive streak maxillary prominence mandibular prominence hand medial ganglionic eminence Gonadal ridge endothelial cell of lymphatic vessel left lung lobe dermis seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding DNA binding SUMO transferase activity ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity DNA topoisomerase binding protein binding transferase activity Cellular component ciliary basal body PML body nuclear speck spindle pole ubiquitin ligase complex gamma-tubulin complex photoreceptor connecting cilium midbody cytoplasmic dynein complex centriole nucleus nucleoplasm Biological process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator retina layer formation ubiquitin-dependent protein catabolic process protein polyubiquitination negative regulation of apoptotic process retinal cone cell development protein monoubiquitination photoreceptor cell outer segment organization protein sumoylation transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated protein K48-linked ubiquitination regulation of cell population proliferation positive regulation of ubiquitin-protein transferase activity retinal rod cell development intrinsic apoptotic signaling pathway in response to DNA damage protein localization to nucleus maintenance of protein location in nucleus proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10210 106021 Ensembl n/a ENSMUSG00000036822 UniProt Q9NS56 Q80Z37 RefSeq (mRNA) NM_005802 NM_001195622 NM_134097 RefSeq (protein) NP_001182551 NP_005793 NP_598858 Location (UCSC) n/a Chr 4: 40.26 – 40.27 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Zhou R, Wen H, Ao SZ (1999). "Identification of a novel gene encoding a p53-associated protein". Gene. 235 (1–2): 93–101. doi:10.1016/S0378-1119(99)00203-6. PMID 10415337.
• Souto-Carneiro MM, Krenn V, Hermann R, et al. (2001). "IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process". Arthritis Res. 2 (4): 303–14. doi:10.1186/ar105. PMC 17813. PMID 11056671.
• Chu D, Kakazu N, Gorrin-Rivas MJ, et al. (2001). "Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence" (PDF). J. Biol. Chem. 276 (17): 14004–13. doi:10.1074/jbc.M010262200. hdl:2433/150162. PMID 11278651. S2CID 20734219.
• Weger S, Hammer E, Heilbronn R (2002). "Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression". J. Gen. Virol. 83 (Pt 3): 511–6. doi:10.1099/0022-1317-83-3-511. PMID 11842245.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Weger S, Hammer E, Engstler M (2003). "The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation". Exp. Cell Res. 290 (1): 13–27. doi:10.1016/S0014-4827(03)00292-1. PMID 14516784.
• Saleem A, Dutta J, Malegaonkar D, et al. (2004). "The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor". Oncogene. 23 (31): 5293–300. doi:10.1038/sj.onc.1207700. PMID 15107820.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rajendra R, Malegaonkar D, Pungaliya P, et al. (2004). "Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53". J. Biol. Chem. 279 (35): 36440–4. doi:10.1074/jbc.C400300200. PMID 15247280.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Oyanagi H, Takenaka K, Ishikawa S, et al. (2005). "Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer". Lung Cancer. 46 (1): 21–8. doi:10.1016/j.lungcan.2004.03.009. hdl:2433/145282. PMID 15364129. S2CID 33682022.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Flatten K, Dai NT, Vroman BT, et al. (2005). "The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons". J. Biol. Chem. 280 (14): 14349–55. doi:10.1074/jbc.M411890200. PMID 15699047.
• Lin L, Ozaki T, Takada Y, et al. (2005). "topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage". Oncogene. 24 (21): 3385–96. doi:10.1038/sj.onc.1208554. PMID 15735665.
• Weger S, Hammer E, Heilbronn R (2005). "Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo". FEBS Lett. 579 (22): 5007–12. doi:10.1016/j.febslet.2005.07.088. PMID 16122737. S2CID 40285751.
• Papaioannou M, Chakarova CF, Prescott DC, et al. (2006). "A new locus (RP31) for autosomal dominant retinitis pigmentosa maps to chromosome 9p". Hum. Genet. 118 (3–4): 501–3. doi:10.1007/s00439-005-0063-3. PMID 16189705. S2CID 28018465.

External links

• TOPORS human gene location in the UCSC Genome Browser.
• TOPORS human gene details in the UCSC Genome Browser.