Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene.[3][4][5][6]

TP53I3
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesTP53I3, PIG3, tumor protein p53 inducible protein 3
External IDsOMIM: 605171; HomoloGene: 36617; GeneCards: TP53I3; OMA:TP53I3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206802
NM_004881
NM_147184

n/a

RefSeq (protein)

NP_001193731
NP_004872
NP_671713

n/a

Location (UCSC)Chr 2: 24.08 – 24.09 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115129Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Contente A, Dittmer A, Koch MC, Roth J, Dobbelstein M (Mar 2002). "A polymorphic microsatellite that mediates induction of PIG3 by p53". Nat Genet. 30 (3): 315–20. doi:10.1038/ng836. PMID 11919562. S2CID 19112465.
  4. ^ Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA (Jul 2000). "p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest". Cancer Lett. 156 (1): 63–72. doi:10.1016/S0304-3835(00)00441-9. PMID 10840161.
  5. ^ Porte S, Valencia E, Yakovtseva EA, Borras E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farres J, Fita I, Pares X (Jun 2009). "Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3". J Biol Chem. 284 (25): 17194–205. doi:10.1074/jbc.M109.001800. PMC 2719357. PMID 19349281.
  6. ^ a b "Entrez Gene: TP53I3 tumor protein p53 inducible protein 3".

Further reading

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